Python can only assign a value to one variable at once, and it must be on the left-hand side of the equals sign. Other variables can appear on the right, but they must be variables that have already been assigned values.
These limitations ensure that when Python is simplifying an expression, there aren't any variables left over: every variable in the expression can be replaced with a value, so the whole expression can be reduced down to a single number (or some other kind of value). Python only has to keep track of the current value of each variable, and it never has to remember an equation.